MonoSpin™ Series (Product Features)

 

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Features

  • Easy to Operate

Easy operation by centrifuge, also multiple samples are processed simultaneously. With little or no liquid retained by the separation material, elution is processed efficiently.

  • Fast

Excellent mass transfer and rapid sample binding on MonoSpin’s monolith silica allows extremely rapid sample preparation compared with other methods.

  • Ideal for Small Sample Volume

Excellent for the pretreatment for samples of 50 – 800 μL

  • Wide Variety of Functional Groups

10 kinds of functional groups are available for MonoSpin series, allowing almost any type of compounds to be purified.

 

How to Operate

How To Operate

 

Application

  • Drugs in Urine (MonoSpin C18)

MonoSpin C18 has been used to rapidly enrich and concentrate drug compounds and their metabolites from urine, as detailed below.

MonoSpin C18 Application

MonoSpin C18-Drugs in Urine

 HPLC Conditions ;

Column : C18 Column (150 × 4.6 mm I.D.)
Eluent : CH3CN/0.1 % H3PO4, 20 mM IPCC-08 =25/75
Flow Rate : 1mL/min
Detection : UV 215 nm(PDA Detector)
Injection Vol : 10 μL
Analyte : Methamphetamine(MA)
       Amphetamine(AP)
       3,4-Methylenedioxymethamphetamine(MDMA)
       3,4-methylenedioxyamphetamine(MDA)

<J. Chromatogr A 1208 (2008) 71-75>

Reference

Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography-diode array detection
J Chromatogr A. 2008 Oct 24;1208(1-2): 71-5

Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1; 872(1-2): 186-90

Simultaneous determination of amitraz and its metabolite in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1): 99-104.

 

  • Purification of pyridylaminated saccharides (MonoSpin NH2)

MonoSpin NH2 shows up to 100% recovery of the pyridylaminated saccharides from original impure sample.

MonoSpin NH2 Application

Purification of Pyridylaminated saccharides

 

  • Recovery of basic drugs in serum (MonoSpin SCX)

MonoSpin SCX Application

MonoSpin SCX Applicaion

HPLC Conditions ;

Column : Inertsil ODS-3 (150 × 4.6 mm I.D.)
Eluent : CH3CN / 5 mM KH2PO4 , 52 mM SDS = 48/52
Flow Rate : 1.0 mL/min
Col. Temp : 40 °C
Detection : 230 nm
Injection Vol : 5 μL

 

  • Catecholamines in Urine (MonoSpin PBA)

Cis-diol compounds and catecholamines can be purifi ed & enriched by MonoSpin PBA.

MonoSpin PBA-Application

MonoSpin PBA

 

  • Phosphoric Amino Herbicides in Urine (MonoSpin TiO)

Phosphoric amino herbicides can be selectively purified and enriched from of complex matrices such as urine.

MonoSpin TiO-Applicaion

MonoSpin TiO

 

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