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NOTICE OF THE 51st ANNUAL GENERAL MEETING OF SHAREHOLDERS

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Specification Change Notice 170328

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Hexamethylenetetramine which was assumed as a precursor compound of formaldehyde is a high polar compound and is difficult to be retained on ODS columns.

In this technical note, we introduce the analysis of Hexamethylenetetramine using 4000 QTRAP® LC/MS/MS System (AB SCIEX) and Inertsil Amide column.

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< Food >
LL009:Analysis of Dipeptide type sweetners

< Pharmacopoeia >
LB280:Analysis of Miglitol (Under the Condition of the draft for the Japanese Pharmacopoeia, Miglitol Tablets)
LB281:Analysis of Montelukast sodium (Inertsil Ph) (Under the Condition of the draft for the Japanese 
           Pharmacopoeia, Montelukast sodium Tablets)
LB282:Analysis of Povidone (Under the Condition of the Japanese Pharmacopoeia, (4) 1-Vinyl-2-pyrrolidone)
LB283:Analysis of Silodosin (Under the Condition of the draft for the Japanese Pharmacopoeia)
LB284:Analysis of Silodosin (Under the Condition of the draft for the Japanese Pharmacopoeia)
LB285:Analysis of Ribavirin (Under the Condition of the draft for the Japanese Pharmacopoeia)
LB286:Analysis of Ribavirin (Under the Condition of the draft for the Japanese Pharmacopoeia)LB287:Analysis of Sugar Spheres (Under the Condition of USP 37-NF32)
LB288:Analysis of Hydrogenated Maltose Starch Syrup (Under the Condition of the JPE (Japanese 
           Pharmaceutical Excipients))

>>>>>   InertSearch

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■ Separation of compounds from small to large molecules

■ A radically new Steel-Coated-PEEK hardware preventing adsorption of peaks

■ Suitable for analyzing Phosphate compounds WITHOUT the formation of
phosphate-iron complexes found with stainless steel column hardwares

■ Extreme resistance to low and high pH mobile phases

■ Endlessly reproducible from column-to-column and batch-to-batch for consistent results

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<Pharmacopoeia>
LB267:Analysis of D-Mannitol

<Pharmaceutical>
LB268:Analysis of Tetracyclines with InertSustain C18
LB269:Analysis of Tetracyclines with InertSustainSwift C18

<InertSustainSwift C18 Applications>
LB270:Analysis of β-blocker
LB271:Analysis of Tulathromycin

< InertSustain Phenylhexyl Applications>
LB272:Analysis of Ibuprofen and Indometacin
LB273:Analysis of Vitamin B
LB274:Analysis of Capsaicin
LB275:Analysis of Histamine antagonist
LB276:Analysis of Anti-depressant drugs
LB277:Analysis of β-blocker
LB278:Analysis of Calcium antagonist
LB279:Analysis of Indometacin (Under the Condition of European Pharmacopoeia 8.2)

>>>>>   InertSearch

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<Pharmacopoeia>
LB250:Analysis of Azelnidipine (Under the Condition of the Japanese Pharmacopoeia)
LB251:Analysis of Quetiapine fumarate (Under the Condition of the Japanese Pharmacopoeia, Quetiapine   
           fumarate Tablets)
LB252:Analysis of Glimepiride
LB253:Analysis of Tranilast (Under the Condition of the Japanese Pharmacopoeia, Tranilast Capsules)
LB254:Analysis of Brotizolam (Under the Condition of the Japanese Pharmacopoeia, Brotizolam Tablets)
LB262:Analysis of Losartan Potassium and Hydrochlorothiazide (Under the Condition of the Japanese
           Pharmacopoeia, Losartan Potassium and Hydrochlorothiazide Tablets)
LB263:Analysis of Losartan Potassium and Hydrochlorothiazide (Under the Condition of the Japanese
           Pharmacopoeia, Losartan Potassium and Hydrochlorothiazide Tablets)
LB264:Analysis of Losartan Potassium and Hydrochlorothiazide (Under the Condition of the Japanese
           Pharmacopoeia, Losartan Potassium and Hydrochlorothiazide Tablets)

<Pharmaceutical>
LB256:Analysis of Nucleobase (InertSustain C18)
LB257:Analysis of Nucleobase (InertSustain Phenyl)

<Others>
LB255:Analysis of Pullulan
LB258:Analysis of Tetracyclines
LB259:Analysis of Tryptic digest of proteins
LB260:Analysis of Chlorophenol
LB261:Analysis of 18 Drugs
LB266:Analysis of Acetic acid and Acrylamide

>>>>>   InertSearch

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■ Different selectivity to C18 phases

■ Strong Retentivity than other Phenyl phases

■ Highly inert packing material results in less tailing of peaks for virtually any type of analytes

■ Deliver extreme sensitivity analysis in LC-MS and LC-MS/MS methods

■ Extreme resistance to low and high pH mobile phases

■ Excellent stability to 100 % aqueous mobile phases

■ Compatible with The European Pharmacopeia (Ph. Eur.) methods

■ Endlessly reproducible from column-to-column and batch-to-batch

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 ACHIEVING SEPARATIONS FASTER THAN EVER BEFORE

Benefits

■ Rapid elution of samples in isocratic methods

■ Rapid column equilibration

■ Highly inert packing material results in less tailing of peaks for virtually any type of analytes

■ Deliver extreme sensitivity analysis in LC-MS and LC-MS/MS methods with low column bleed

■ Extreme resistance to low and high pH mobile phases

■ Excellent stability to 100 % aqueous mobile phases

■ Endlessly reproducible from column-to-column and batch-to-batch

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<Food Applications>

      LB233 – 234 Analysis of Amino acids
      LB235 – 242 Analysis of Preservatives and Sweetener

<Pharmaceutical Application>

      LB230 – 232 Analysis of Leuprorelin acetate
      LB243         Analysis of Acarbose
      LB244         Analysis of Calcium pantothenate
                        (Under the Condition of the draft for the Japanese Pharmacopoeia,
                                                                                      L-Carbocisteine Tablets)
      LB245         Analysis of L-Carbocisteine
                         (Under the Condition of the draft for the Japanese Pharmacopoeia,
                                                                           L-Carbocisteine Tablets, eluting)
      LB246         Analysis of L-Carbocisteine
                         (Under the Condition of the draft for the Japanese Pharmacopoeia,
                                                        L-Carbocisteine Tablets, quantitation method)
      LB247         Analysis of Terbinafine hydrochloride
                         (Under the Japanese Pharmacopoeia, Terbinafine hydrochloride salt cream
                                                                                                        quantitation method)

<Other Applications>

      LB248 – 249 Analysis of Organic electroluminescence materials

InertSustainSwift C18 Application
LB230, LB231, LB232, LB233, LB234, LB236, LB239, LB247

>>>>>  InertSearch

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LL008:Simultaneous analysis of 22 amino acids derivatized with 4-fluoro-7-nitro-2,1,3,-benzoxadiazole

LB222:Analysis of Butenafine hydrochloride (Under the Condition of the Japanese Pharmacopoeia)

LB223:Analysis of Cilnidipine
(Under the Condition of the draft for the Japanese Pharmacopoeia,Cilnidipine Tablets)

LB227:Analysis of Tocopherol (Inertsil ODS-2)

LB228:Analysis of Polyvinyl alcohol, Polyethyleneglycol and Graft copolymer
(Under the Condition of the JPE(Japanese Pharmaceutical Excipients), (3) Acetic acid)

LB229:Analysis of Polyvinyl alcohol, Polyethyleneglycol and Graft copolymer
(Under the Condition of the JPE (Japanese Pharmaceutical Excipients), (4) Vinyl acetate)

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InertSustainSwift C18 is an optimal column for high throughput analysis designed for elution time to be faster and shorten an equilibration time also in gradient analysis.Moreover, it has the inactive processing technology acquired by InertSustain C18, and has become a column which combines high durability and low bleeding.

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We are pleased to inform that Teknolab AS contact information is updated as our distributor in Norway.

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<LB200> Losartan potassium and Hydrochlorothiazide under U.S. Pharmacopeia

<LB201> Candesartan cilexetil (Purity Test Under Japanese Pharmacopoeia)

<LB202> Candesartan cilexetil (Elution Test Under Japanese Pharmacopoeia)

<LB203> Candesartan cilexetil (Quantitative Under Japanese Pharmacopoeia)

<LB204> Metformin hydrochloride Analysis(Quantitative Under Japanese Pharmacopoeia)

<LB205> Paroxetine hydrochloride (Elution Test Under Japanese Pharmacopoeia)

<LB206> Paroxetine hydrochloride (Quantitative Under Japanese Pharmacopoeia)

<LB207> Analysis of Montelukast sodium

<LB208> Analysis of Montelukast sodium (Oxidative degradation products)

<LB209> Pioglitazone hydrochloride (Purity Test Under Japanese Pharmacopoeia

<LB210> Pioglitazone hydrochloride (Quantitative Under Japanese Pharmacopoeia)

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