Adjustable range of chromatography conditions has been specified in [2.00 General theory of chromatography] which has been stipulated based on the contents harmonized and agreed upon by Japanese/U.S./European Trilateral Pharmacopoeia at the first supplemental public comment of the Japanese Pharmacopoeia,
18th Edition, which was disclosed in September 2021.
Based on this, the speed-up of analysis can be expected by optimizing the column size and analytical conditions within the acceptable changeable range.
In this report, an example of analysis was reported, in which analysis time is shortened and solvents consumption is reduced by changing the conditions within the range specified in [2.00 General theory of chromatography] for JP18 Test for Quantitative Method of Tranexamic Acid.
* The change of analytical conditions is for the content to be applied from the first supplemental revision of JP18 and is not for the content announced in the past. Accordingly, this Technical Note is simply just for reference.