Proteomics Related Products

Titansphere TiO Bulk Material

Titansphere TiO 充填剤の画像

GL Sciences provides titania dioxide (Titansphere series) which absorb with phosphorylated peptide.


  • Spherically shaped porous particle
    • Easy to pack into a tip
  • Wide Surface Area
    • Provide a high recovery rate even with small amount of sample
  • Wide Application Range
    • Since it can specifically adsorb phosphate sites, it can be applicable to the purification of phosphorylated peptides, phosphorylated sugars, glyphosate, etc.


Particle Size
5 µm, 10 µm
Particle Shape
Maximum operating pressure
19.8 MPa (198 bar)
Titanium Dioxide Crystal
Pore Size
100 Å (10 nm)
Surface Area
100 m2/g
pH Range
2 - 12
Binding Capacity
400 ng/mg   Tyr(PO3H2)-Angiotensin II


1. Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications, Sugiyama N, Masuda T, Shinoda K, Nakamura A, Tomita M, Ishihama Y., Mol Cell Proteomics. 2007 Jun;6(6):1103-9.

2. Highly selective enrichment of phosphorylated peptides using titanium dioxide, Nature Protocols 1, 2006, 1929-1935

3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks, Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M., Cell. 2006 Nov 3;127(3):635-48.

4. Successive and selective release of phospholylated Peptides captured by Hydroxy Acid-Modified Metal Oxide Chromatography, Yutaka Kyono, Naoyuki Sugiyama, Koshi Imami, Masaru Tomita, and Yasushi Ishihama, J Proteome Res., 2008, 7(10), 4585-93

5. Extended coverage of singly and multiply phosphorylated peptides from a single Titanium Dioxide Microcolumn, Anal Chem., 2015, 87(20), 10213-21

DescriptionParticle SizeSDSQty.Cat.No.
Titansphere TiO5µmENG500mg5020-75000
Titansphere TiO10µmENG500mg5020-75010