Polymer Based SPE (Ion Exchange)

InertSep Oligo SPE

• Catalog

InertSep Oligo is a WAX-based solid-phase extraction (SPE) product engineered for oligonucleotide sample preparation in LC/MS workflows. It delivers high recovery, low variability, and complete LC/MS compatibility—key to reliable quantitation when distinguishing parent oligonucleotides from metabolites.

Oligonucleotide therapeutics are gaining momentum for their high target specificity and low toxicity. While ligand-binding assays remain widely used, LC/MS methods are increasingly preferred in parts of development due to superior selectivity. In these workflows, robust, reproducible sample prep is essential.

InertSep Oligo supports both manual and automated high-throughput processing with multiple format options:

• 96-Well Plate Format
– Micro Elution: 2 mg / 400 µL
– 2 mL square-well: 25 mg / 2 mL

• Straight Barrel Cartridge Format
– 10 mg / 1 mL
– 30 mg / 3 mL
– 60 mg / 3 mL
– 150 mg / 6 mL

All formats use the same WAX sorbent, ensuring consistent performance across scales and platforms.